LEAPChem Blog

2018年10月18日星期四

LEAPChem Highlights Benzyladenine (1214-39-7)!

At LEAPChem - Pharmaceutical Chemicals, we proudly distribute the materials that are required for the wide range of our customers’ production processes. We understand that each production process is unique, which is why we provide custom services and chemical knowledge tailored to each customer specifically. With LEAPChem, you can look forward to receiving the operational benefits of working with an international company paired with the customer service and reliable follow up of a small business. We offer various pack sizes and configurations to suit your needs, and our experienced staff stays with you every step of the way, from inquiry through delivery. One such material is our current featured product, Benzyladenine.

Basic Information of Benzyladenine

Chemical Name: Benzyladenine

Cas No.: 1214-39-7

Molecular Formula: C12H11N5

Chemical Structure:

6-Benzylaminopurine, benzyl adenine or BAP is a first-generation synthetic cytokinin that elicits plant growth and development responses, setting blossoms and stimulating fruit richness by stimulating cell division. It is an inhibitor of respiratory kinase in plants, and increases post-harvest life of green vegetables. Influence of cytokinin as 6-benzylaminopurine (BAP) in combination with other methods on postharvest green color retention on broccoli heads and asparagus spears, showed positive results for quality retention. Treatment with 10 and 15 ppm BAP can be used to extend shelf life of fresh-cut broccoli florets and shredded cabbage during storage at 6±1°C at commercial level.

6-Benzyladenine, also called 6-benzylaminopurine, is a synthetic cytokinin that stimulates cell division in plants. Among other actions, it spurs plant growth, sets blossoms, and improves fruit quality.

Cytokinins are in the plant growth hormone family. As part of his pioneering research in plant growth regulators, plant physiologist Folke K. Skoog at the University of Wisconsin–Madison synthesized 6-benzyladenine and demonstrated its efficacy.

In a recent C&EN “Periodic Graphics” page, author Andy Brunning included 6-benzyladenine in a roundup of how “flower food” helps to preserve cut flowers. He notes that the growth regulator’s contribution to preservation is maintaining petal colors. 6-Benzyladenine is similarly used to extend the shelf lives of broccoli florets and shredded cabbage to make them more attractive to customers.

LEAPChem is continually expanding its scope within the pharmaceutical chemicals industry. Our passion for professional development enables us to accommodate our customers’ chemical requirements, and to distribute chemicals with applications that span several classes and functions.

If you are interested in Benzyladenine, click here to send an inquiry!

Make LEAPChem your pharmaceutical chemicals long-term partner and contact us today!

References:

https://en.wikipedia.org/wiki/6-Benzylaminopurine

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1067083/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC396646/

LEAPChem Supplies 2,2,2-Trifluoroethanol (75-89-8) Now!

LEAPChem Highlights Saponin (8047-15-2) Today!

Buy Daptomycin (103060-53-3) from LEAPChem!

2018年10月17日星期三

Find Dimethyl fumarate (624-49-7) on LEAPChem.com!

LEAPChem - Pharmaceutical Chemicals is a premier supplier of pharmaceutical chemicals and other chemical raw materials for global customers including drug manufacturers, universities, research labs, R&D centers, and other industries that use chemical raw materials such as polymers, textiles, agriculture, coatings, etc. As an ISO 9001:2015 certified company, our team of experts in customer service, product sourcing, logistics, regulatory and compliance operate at the highest standard. LEAPChem's experienced sales team will work tirelessly to find the chemicals you need for a price you can afford. One such material is our current featured product, Dimethyl fumarate.

Basic Information of Dimethyl fumarate

Chemical Name: Dimethyl fumarate

Cas No.: 624-49-7

Molecular Formula: C6H8O4

Chemical Structure:

Dimethyl fumarate (DMF) is the methyl ester of fumaric acid. DMF was initially recognized as a very effective hypoxic cell radiosensitizer. Later, DMF combined with three other fumaric acid esters (FAE) was licensed in Germany as oral therapy for psoriasis (trade name Fumaderm). Other diseases, such as necrobiosis lipoidica, granuloma annulare, and sarcoidosis were also found to respond to treatment with DMF in case reports or small patient series. Phase III clinical trials found that DMF (BG-12) successfully reduced relapse rate and increased time to progression of disability in multiple sclerosis (trade name Tecfidera). DMF is thought to have immunomodulatory properties without significant immunosuppression.

Dimethyl fumarate was shown to have a significant effect on relapse rate and time to progression in phase III clinical trials of multiple sclerosis. Several methods exist for the laboratory synthesis of dimethyl fumarate, with reported methods alkene isomerization of dimethyl maleate, and Fischer esterification of fumaric acid. Dimethyl fumarate is an ester and an α,β-unsaturated electrophilic compound which can quickly undergo Michael additions with nucleophiles. Dimethyl fumarate is also an effective diene acceptor in the thermal Diels-Alder reaction, where the reactivity of its vinylenic bond is enhanced by the two electron-withdrawing ester groups. Due to the geometry of the starting ester, the Diels-Alder product will have a trans configuration. With this reaction, compounds with bicyclo skeletons can be synthesized, e.g. a diester with a norbornene skeleton from dimethyl fumarate and cyclopentadiene.

We offer various pack sizes and configurations to suit your needs, and our experienced staff stays with you every step of the way, from inquiry through delivery.

If you are interested in Dimethyl fumarate, click here to send an inquiry!

Make LEAPChem your pharmaceutical chemicals long-term partner and contact us today!

References:

https://en.wikipedia.org/wiki/Dimethyl_fumarate

https://www.ncbi.nlm.nih.gov/pubmed/29128972

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4780395/

LEAPChem Supplies 2,2,2-Trifluoroethanol (75-89-8) Now!

LEAPChem Highlights Saponin (8047-15-2) Today!

Buy Daptomycin (103060-53-3) from LEAPChem!

2018年10月15日星期一

LEAPChem Highlights Dextran (9004-54-0)!

Basic Information of Dextran

Chemical Name: Dextran

Cas No.: 9004-54-0

Molecular Formula: H(C6H10O5)xOH

Chemical Structure:

Dextran is a complex branched glucan (polysaccharide made of many glucose molecules) composed of chains of varying lengths (from 3 to 2000 kilodaltons). The straight chain consists of α-1,6 glycosidic linkages between glucose molecules, while branches begin from α-1,3 linkages. This characteristic branching distinguishes a dextran from a dextrin, which is a straight chain glucose polymer tethered by α-1,4 or α-1,6 linkages.

Medicinally it is used as an antithrombotic (antiplatelet), to reduce blood viscosity, and as a volume expander in hypovolaemia. Dextran 70 is on the WHO Model List of Essential Medicines, the most important medications needed in a health system.

These agents are used commonly by microsurgeons to decrease vascular thrombosis. The antithrombotic effect of dextran is mediated through its binding of erythrocytes, platelets, and vascular endothelium, increasing their electronegativity and thus reducing erythrocyte aggregation and platelet adhesiveness. Dextrans also reduce factor VIII-Ag Von Willebrand factor, thereby decreasing platelet function. Clots formed after administration of dextrans are more easily lysed due to an altered thrombus structure (more evenly distributed platelets with coarser fibrin. By inhibiting α-2 antiplasmin, dextran serves as a plasminogen activator, so possesses thrombolytic features.

Although relatively few side effects are associated with dextran use, these side effects can be very serious. These include anaphylaxis, volume overload, pulmonary edema, cerebral edema, or platelet dysfunction. An uncommon but significant complication of dextran osmotic effect is acute renal failure. The pathogenesis of this renal failure is the subject of many debates with direct toxic effect on tubules and glomerulus versus intraluminal hyperviscosity being some of the proposed mechanisms. Patients with history of diabetes mellitus, renal insufficiency, or vascular disorders are most at risk. Brooks and others recommend the avoidance of dextran therapy in patients with chronic renal insufficiency.

We offer various pack sizes and configurations to suit your needs, and our experienced staff stays with you every step of the way, from inquiry through delivery.

If you are interested in Dextran, click here to send an inquiry!

Make LEAPChem your pharmaceutical chemicals long-term partner and contact us today!

References:

https://en.wikipedia.org/wiki/Dextran

https://pubchem.ncbi.nlm.nih.gov/compound/Dextran

https://www.ncbi.nlm.nih.gov/pubmed/23609045

LEAPChem Hightlights N,N-Dimethylformamide dimethyl acetal (4637-24-5)!

Find Hydroxylamine hydrochloride (5470-11-1) on LEAPChem!

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LEAPChem Supplies Pyriproxyfen (95737-68-1) Now!

As an industry leader in chemical sourcing, LEAPChem - Pharmaceutical Chemicals has strong relationships with vendors, suppliers, and customers worldwide that allow us to access hard to find chemicals at competitive prices. Our warehouses are equipped to handle kosher, organic, hazardous, and non-hazardous materials. We have established partnerships with import and export providers making seamless international shipping possible. At LEAPChem, we proudly distribute the materials that are required for the wide range of our customers’ production processes. We understand that each production process is unique, which is why we provide custom services and chemical knowledge tailored to each customer specifically. With LEAPChem, you can look forward to receiving the operational benefits of working with an international company paired with the customer service and reliable follow up of a small business. LEAPChem is happy to highlight Pyriproxyfen.

Basic Information of Pyriproxyfen

Chemical Name: Pyriproxyfen

Cas No.: 95737-68-1

Molecular Formula: C20H19NO3

Chemical Structure:

Pyriproxyfen is a pyridine-based pesticide which is found to be effective against a variety of arthropoda. It was introduced to the US in 1996, to protect cotton crops against whitefly. It has also been found useful for protecting other crops. It is also used as a prevention for flea control on household pets, for killing indoor and outdoor ants and roaches. Methods of application include aerosols, bait, carpet powders, foggers, shampoos and pet collars.

Pyriproxyfen is a juvenile hormone analog and an insect growth regulator. It prevents larvae from developing into adulthood and thus rendering them unable to reproduce.

Pyriproxyfen is an insect growth regulator. It mimics natural insect hormones that stop young insects from maturing into adults. Pyriproxyfen can affect an insect if it is touched or eaten. However, pyriproxyfen is rarely toxic to adult insects. Instead, it disturbs egg-laying and egg-hatch and keeps young insects from growing into adult forms. This prevents target insects from multiplying.

If you are interested in Pyriproxyfen, click here to send an inquiry!

Make LEAPChem your pharmaceutical chemicals long-term partner and contact us today!

References:

https://en.wikipedia.org/wiki/Pyriproxyfen

https://pubchem.ncbi.nlm.nih.gov/compound/Pyriproxyfen

https://www.ncbi.nlm.nih.gov/pubmed/27613592

LEAPChem Hightlights N,N-Dimethylformamide dimethyl acetal (4637-24-5)!

Find Hydroxylamine hydrochloride (5470-11-1) on LEAPChem!

Buy Dicyclohexylcarbodiimide (538-75-0) on LEAPChem!

2018年9月21日星期五

LEAPChem Highlights Diethyl pyrocarbonate (1609-47-8)!

As an industry leader in chemical sourcing, LEAPChem - Pharmaceutical Chemicals combines experience and expertise in the distribution of hazardous and non-hazardous raw materials to its professional customer base. Working alongside an elite network of manufacturers, carriers and warehouses, we are equipped to deliver your product safely and efficiently, throughout every step of the supply chain. We offer various pack sizes and configurations to suit your needs, and our experienced staff stays with you every step of the way, from inquiry through delivery. LEAPChem is happy to highlight Diethyl pyrocarbonate.

Basic Information of Diethyl pyrocarbonate

Chemical Name: Diethyl pyrocarbonate

Cas No.: 1609-47-8

Molecular Formula: C6H10O5

Chemical Structure:

Diethyl pyrocarbonate (DEPC), also called diethyl dicarbonate (IUPAC name), is used in the laboratory to inactivate RNase enzymes in water and on laboratory utensils. It does so by the covalent modification of histidine (most strongly), lysine, cysteine, and tyrosine residues.

DEPC-treated (and therefore RNase-free) water is used in handling of RNA in the laboratory to reduce the risk of RNA being degraded by RNases.

Water is usually treated with 0.1% v/v DEPC for at least 2 hours at 37 °C and then autoclaved (at least 15 min) to inactivate traces of DEPC. Inactivation of DEPC in this manner yields CO2 and ethanol. Higher concentrations of DEPC are capable of deactivating larger amounts of RNase, but remaining traces or byproducts may inhibit further biochemical reactions such as in vitro translation. Furthermore, chemical modification of RNA such as carboxymethylation is possible when traces of DEPC or its byproducts are present, resulting in impaired recovery of intact RNA even after buffer exchange (after precipitation).

DEPC is unstable in water and susceptible to hydrolysis to carbon dioxide and ethanol, especially in the presence of a nucleophile. For this reason, DEPC cannot be used with Tris or HEPES buffers. In contrast, it can be used with phosphate-buffered saline or MOPS. A handy rule is that enzymes or chemicals which have active -O:, -N: or -S: cannot be treated with DEPC to become RNase-free, as DEPC reacts with these species. Furthermore, DEPC degradation products can inhibit in vitro transcription.

DEPC derivatization of histidines is also used to study the importance of histidyl residues in enzymes. Modification of histidine by DEPC results in carbethoxylated derivates at the N-omega-2 nitrogen of the imidazole ring. DEPC modification of histidines can be reversed by treatment with 0.5 M hydroxylamine at neutral pH.

DEPC can also be used for probing the structure of double-stranded DNA.

LEAPChem is committed to providing our customers with quality products and services. With a varied and vetted collective of suppliers, LEAPChem can provide products to meet any of your specifications and needs.

If you are interested in Diethyl pyrocarbonate, click here to send an inquiry!

Make LEAPChem your pharmaceutical chemicals long-term partner and contact us today!

References:

https://en.wikipedia.org/wiki/Diethyl_pyrocarbonate

https://pubchem.ncbi.nlm.nih.gov/compound/diethyl_pyrocarbonate

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC339840/

LEAPChem Hightlights N,N-Dimethylformamide dimethyl acetal (4637-24-5)!

Find Hydroxylamine hydrochloride (5470-11-1) on LEAPChem!

Buy Dicyclohexylcarbodiimide (538-75-0) on LEAPChem!

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