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LEAPChem Highlights Sildenafil citrate today!
Basic
Information of Sildenafil citrate
Chemical Name: Sildenafil citrate
Cas No.: 171599-83-0
Molecular Formula: C11H8O2
Chemical Structure:
Sildenafil, sold as
the brand name Viagra among others, is a medication used to treat erectile
dysfunction and pulmonary arterial hypertension.
Its effectiveness for treating sexual
dysfunction in women has not been demonstrated.
Common side effects include headaches and
heartburn, as well as flushed skin. Caution is advised in those who have
cardiovascular disease. Rare but serious side effects include prolonged
erections, which can lead to damage to the penis, and sudden-onset hearing
loss. Sildenafil should not be taken by people who take nitrates such as
nitroglycerin (glycerin trinitrate), as this may result in a severe and
potentially fatal drop in blood pressure.
Sildenafil acts by inhibiting cGMP-specific
phosphodiesterase type 5 (phosphodiesterase 5, PDE5), an enzyme that promotes
degradation of cGMP, which regulates blood flow in the penis.
Pfizer scientists Andrew Bell, David Brown,
and Nicholas Terrett originally discovered sildenafil as a treatment for
various cardiovascular disorders. Since becoming available in 1998, sildenafil
has been a common treatment for erectile dysfunction; its primary competitors
are tadalafil (trade name Cialis) and vardenafil (Levitra).
The primary indication of sildenafil is
treatment of erectile dysfunction (inability to sustain a satisfactory erection
to complete intercourse). Its use is now one of the standard treatments for
erectile dysfunction, including for men with diabetes mellitus.
Tentative evidence suggests that sildenafil
may help men who experience antidepressant-induced erectile dysfunction.
While sildenafil improves some markers of
disease in people with pulmonary arterial hypertension, it does not appear to
affect the risk of death or serious side effects as of 2014.
Sildenafil and other PDE5 inhibitors are
used off-label to alleviate vasospasm and treat severe ischemia and ulcers in
fingers and toes for people with secondary Raynaud's phenomenon; these drugs
have moderate efficacy for reducing the frequency and duration of vasospastic
episodes. As of 2016, their role more generally in Raynaud's was not clear.
Sildenafil protects cyclic guanosine
monophosphate (cGMP) from degradation by cGMP-specific phosphodiesterase type 5
(PDE5) in the corpus cavernosum. Nitric oxide (NO) in the corpus cavernosum of
the penis binds to guanylate cyclase receptors, which results in increased
levels of cGMP, leading to smooth muscle relaxation (vasodilation) of the
intimal cushions of the helicine arteries. This smooth muscle relaxation leads
to vasodilation and increased inflow of blood into the spongy tissue of the
penis, causing an erection. Robert F. Furchgott, Ferid Murad, and Louis Ignarro
won the Nobel Prize in Physiology or Medicine in 1998 for their independent
study of the metabolic pathway of nitric oxide in smooth muscle vasodilation.
As a verified ISO:9001 certified
organization, we at LEAPChem demonstrate a high level of care in the
distribution of our vast catalog of raw materials—accurately, on time, and on
budget—by way of our knowledgeable sales specialists, thorough customer service
and compliance departments, and cost-effective logistics management.
If you are interested in Sildenafil citrate, click here to send an inquiry!
Make LEAPChem your pharmaceutical chemicals
long-term partner and contact
us today!
References:
https://en.wikipedia.org/wiki/Sildenafil
https://www.ncbi.nlm.nih.gov/pubmed/11220982
https://www.ncbi.nlm.nih.gov/pubmed/10400408
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