LEAPChem Highlights Diethyl pyrocarbonate (1609-47-8)!

As an industry leader in chemical sourcing, LEAPChem - Pharmaceutical Chemicals combines experience and expertise in the distribution of hazardous and non-hazardous raw materials to its professional customer base. Working alongside an elite network of manufacturers, carriers and warehouses, we are equipped to deliver your product safely and efficiently, throughout every step of the supply chain. We offer various pack sizes and configurations to suit your needs, and our experienced staff stays with you every step of the way, from inquiry through delivery. LEAPChem is happy to highlight Diethyl pyrocarbonate.

Basic Information of Diethyl pyrocarbonate

Chemical Name: Diethyl pyrocarbonate

Cas No.: 1609-47-8

Molecular Formula: C6H10O5

Chemical Structure:

Diethyl pyrocarbonate (DEPC), also called diethyl dicarbonate (IUPAC name), is used in the laboratory to inactivate RNase enzymes in water and on laboratory utensils. It does so by the covalent modification of histidine (most strongly), lysine, cysteine, and tyrosine residues.

DEPC-treated (and therefore RNase-free) water is used in handling of RNA in the laboratory to reduce the risk of RNA being degraded by RNases.

Water is usually treated with 0.1% v/v DEPC for at least 2 hours at 37 °C and then autoclaved (at least 15 min) to inactivate traces of DEPC. Inactivation of DEPC in this manner yields CO2 and ethanol. Higher concentrations of DEPC are capable of deactivating larger amounts of RNase, but remaining traces or byproducts may inhibit further biochemical reactions such as in vitro translation. Furthermore, chemical modification of RNA such as carboxymethylation is possible when traces of DEPC or its byproducts are present, resulting in impaired recovery of intact RNA even after buffer exchange (after precipitation).

DEPC is unstable in water and susceptible to hydrolysis to carbon dioxide and ethanol, especially in the presence of a nucleophile. For this reason, DEPC cannot be used with Tris or HEPES buffers. In contrast, it can be used with phosphate-buffered saline or MOPS. A handy rule is that enzymes or chemicals which have active -O:, -N: or -S: cannot be treated with DEPC to become RNase-free, as DEPC reacts with these species. Furthermore, DEPC degradation products can inhibit in vitro transcription.

DEPC derivatization of histidines is also used to study the importance of histidyl residues in enzymes. Modification of histidine by DEPC results in carbethoxylated derivates at the N-omega-2 nitrogen of the imidazole ring. DEPC modification of histidines can be reversed by treatment with 0.5 M hydroxylamine at neutral pH.

DEPC can also be used for probing the structure of double-stranded DNA.

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References:

https://en.wikipedia.org/wiki/Diethyl_pyrocarbonate

https://pubchem.ncbi.nlm.nih.gov/compound/diethyl_pyrocarbonate

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC339840/

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Buy 5-Bromo-5-nitro-1,3-dioxane (30007-47-7) from LEAPChem Now!

As an industry leader in chemical sourcing, LEAPChem - Pharmaceutical Chemicals has strong relationships with vendors, suppliers, and customers worldwide that allow us to access hard to find chemicals at competitive prices. Our warehouses are equipped to handle kosher, organic, hazardous, and non-hazardous materials. We have established partnerships with import and export providers making seamless international shipping possible. LEAPChem is happy to highlight 5-Bromo-5-nitro-1,3-dioxane.

Basic Information of 5-Bromo-5-nitro-1,3-dioxane

Chemical Name: 5-Bromo-5-nitro-1,3-dioxane

Cas No.: 30007-47-7

Molecular Formula: C4H6BrNO4

Chemical Structure:

Bronidox, or 5-bromo-5-nitro-1,3-dioxane, is an antimicrobial chemical compound. In cosmetics and personal care products, 5-Bromo-5-Nitro-1,3-Dioxane is used as a preservative in bath, hair and personal cleanliness products. Bronidox causes inhibition of enzyme activity in bacteria. 5-Bromo-5-Nitro-1,3-Dioxane functions as a preservative. It prevents or retards bacterial growth, and thus protects cosmetic and personal care products from spoilage. 5-Bromo-5-Nitro-1,3-Dioxane is a cyclic aliphatic ether. It is also used as a preservative in water systems, paints, cutting oils and in leather processing.

5-bromo-5-nitro-1,3-Dioxane is an antimicrobial compound that is effective against Gram-positive and Gram-negative bacteria and fungi, including yeast. Its mode of action occurs via the oxidation of essential protein thiols causing inhibition of enzyme activity and subsequent inhibition of microbial growth. This compound has been used as a preservative for biological molecules and solutions such as antibodies and antisera.

LEAPChem is committed to providing our customers with quality products and services. With a varied and vetted collective of suppliers, LEAPChem can provide products to meet any of your specifications and needs.

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References:

https://en.wikipedia.org/wiki/Bronidox

https://pubchem.ncbi.nlm.nih.gov/compound/5-Bromo-5-nitro-1_3-dioxane

https://www.ncbi.nlm.nih.gov/pubmed/3082729

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LEAPChem Supplies D-Biotin (58-85-5) Now!

LEAPChem - Pharmaceutical Chemicals is continually expanding its scope within the pharmaceutical chemicals industry. Our passion for professional development enables us to accommodate our customers’ chemical requirements, and to distribute chemicals with applications that span several classes and functions. As the name suggests, LEAPChem pharmaceutical chemicals specializes in providing you with those difficult to acquire niche chemicals. We are, however, just as eager and able to provide widely used and recognized chemicals to our valued clients. One such chemical is D-Biotin.

Basic Information of D-Biotin

Chemical Name: D-Biotin

Cas No.: 58-85-5

Molecular Formula: C10H16N2O3S

Chemical Structure:

Biotin is a water-soluble B-vitamin, also called vitamin B7 and formerly known as vitamin H or coenzyme R.It is composed of a ureido ring fused with a tetrahydrothiophene ring. A valeric acid substituent is attached to one of the carbon atoms of the tetrahydrothiophene ring. Biotin is a coenzyme for carboxylase enzymes, involved in the synthesis of fatty acids, isoleucine, and valine, and in gluconeogenesis.

Biotin deficiency can be caused by inadequate dietary intake or inheritance of one or more inborn genetic disorders that affect biotin metabolism. Subclinical deficiency can cause mild symptoms, such as hair thinning or skin rash typically on the face. Neonatal screening for biotinidase deficiency began in the United States in 1984 and today many countries test for this disorder at birth. Individuals born prior to 1984 are unlikely to have been screened, thus the true prevalence of the disorder is unknown.

D-biotin is the naturally occurring, biologically active form of the B vitamin biotin. It's involved in lipid, protein and carbohydrate metabolism. Because biotin is relatively plentiful among foods and your intestines are even able to produce it, a deficiency is rare and supplements are usually unnecessary unless your doctor recommends them. Foods rich in biotin include eggs, dairy products, peanuts, almonds, walnuts, wheat bran, whole-wheat bread, wild salmon, Swiss chard, cauliflower, avocados and raspberries.

D-biotin is one of eight forms of the water-soluble vitamin, biotin, also known as vitamin B-7. It is a coenzyme -- or helper enzyme -- for numerous metabolic reactions in the body. D-biotin is involved in lipid and protein metabolism and helps convert food into glucose, which the body uses for energy. It's also vital for maintaining skin, hair and mucous membranes

At LEAPChem, we place emphasis on the importance of each step of the distribution process. From sourcing, to supply chain logistics, to customer service, and the technical know-how in between, LEAPChem is a trusted industry leader. We will be the strongest link in your supply chain and help you to get the products you need accurately, on time, and on budget.

If you are interested in D-Biotin, click here to send an inquiry!

Make LEAPChem your pharmaceutical chemicals long-term partner and contact us today!

References:

https://en.wikipedia.org/wiki/Biotin

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4757853/

https://pubchem.ncbi.nlm.nih.gov/compound/biotin

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3509882/

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Find Aluminium isopropoxide (555-31-7) on LEAPChem.com!

LEAPChem - Pharmaceutical Chemicals is a premier supplier of pharmaceutical chemicals and other chemical raw materials for global customers including drug manufacturers, universities, research labs, R&D centers, and other industries that use chemical raw materials such as polymers, textiles, agriculture, coatings, etc. As an ISO 9001:2015 certified company, our team of experts in customer service, product sourcing, logistics, regulatory and compliance operate at the highest standard. LEAPChem's experienced sales team will work tirelessly to find the chemicals you need for a price you can afford. LEAPChem is happy to highlight Aluminium isopropoxide.

Basic Information of Aluminium isopropoxide

Chemical Name: Aluminium isopropoxide

Cas No.: 555-31-7

Chemical Structure:

Aluminium isopropoxide is the chemical compound usually described with the formula Al(O-i-Pr)3, where i-Pr is the isopropyl group (–CH(CH3)2). This colourless solid is a useful reagent in organic synthesis. The structure of this compound is complex, possibly time-dependent, and may depend on solvent. Aluminium isopropoxide is a colorless solid, slightly soluble in alcohols, but more soluble in THF and carbon disulfide. It has the tendency to supercool.

The structure of this compound is complex, possibly time-dependent, and may depend on solvent.

In the laboratory, a widely accepted method for preparing aluminium isopropoxide was published in 1936 by Young, Hartung, and Crossley. Their procedure entails heating a mixture of 100 g of aluminium, 1200 mL of isopropyl alcohol, and 5 g of mercuric chloride at reflux. The process occurs via the formation of an amalgam of the aluminium. A catalytic amount of iodine is sometimes added to initiate the reaction, which can be quite vigorous. Young et al. achieved an 85–90% yield, after purification by distillation at 140–150 °C (5 mm Hg).

In a MPV reduction, ketones and aldehydes are reduced to alcohols concomitant with the formation of acetone. This reduction relies on an equilibrium process, hence it produces the thermodynamic product. Conversely, in the Oppenauer Oxidation, secondary alcohols are converted to ketones, and homoallylic alcohols are converted to α,β-unsaturated carbonyls. In these reactions, it is assumed that the tetrameric cluster disagregates.

LEAPChem combines experience and expertise in the distribution of hazardous and non-hazardous raw materials to its professional customer base. Working alongside an elite network of manufacturers, carriers and warehouses, we are equipped to deliver your product safely and efficiently, throughout every step of the supply chain.

If you are interested in Aluminium isopropoxide, click here to send an inquiry!

Make LEAPChem your pharmaceutical chemicals long-term partner and contact us today!

References:

https://en.wikipedia.org/wiki/Aluminium_isopropoxide

https://pubchem.ncbi.nlm.nih.gov/compound/129694220

https://www.ncbi.nlm.nih.gov/pubmed/20104306

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