LEAPChem Blog: 十月 2018

2018年10月26日星期五

LEAPChem Features Doxorubicin hydrochloride (25316-40-9)!

LEAPChem - Pharmaceutical Chemicals is an ISO:9001 certified organization, which shows our high reputation track record for providing high quality management in the pharmaceutical chemicals industry. From initial inquiry through safe and efficient delivery, our team has the experience and professionalism to secure any pharmaceutical chemicals in your preferred grade, pack size and pack form, and deliver your products accurately, on time and on budget to every corner of the world. LEAPChem Features Doxorubicin hydrochloride today!

Basic Information of Doxorubicin hydrochloride

Chemical Name: Doxorubicin hydrochloride

Cas No.: 25316-40-9

Molecular Formula: C27H29NO11

Chemical Structure:

Doxorubicin, sold under the trade names Adriamycin among others, is a chemotherapy medication used to treat cancer. This includes breast cancer, bladder cancer, Kaposi's sarcoma, lymphoma, and acute lymphocytic leukemia. It is often used together with other chemotherapy agents. Doxorubicin is given by injection into a vein.

Common side effects include hair loss, bone marrow suppression, vomiting, rash, and inflammation of the mouth. Other serious side effects may include allergic reactions such as anaphylaxis, heart damage, tissue damage at the site of injection, radiation recall, and treatment-related leukemia. People often experience red discoloration of the urine for a few days. Doxorubicin is in the anthracycline and antitumor antibiotic family of medications. It works in part by interfering with the function of DNA.

Doxorubicin is commonly used to treat some leukemias and Hodgkin's lymphoma, as well as cancers of the bladder, breast, stomach, lung, ovaries, thyroid, soft tissue sarcoma, multiple myeloma, and others. Commonly used doxorubicin-containing regimens are AC (adriamycin, cyclophosphamide), TAC (taxotere, AC), ABVD (Adriamycin, bleomycin, vinblastine, dacarbazine), BEACOPP, CHOP (cyclophosphamide, hydroxydaunorubicin, vincristine, prednisone) and FAC (5-fluorouracil, adriamycin, cyclophosphamide).

Doxil is used primarily for the treatment of ovarian cancer where the disease has progressed or recurred after platinum-based chemotherapy, or for the treatment of AIDS-related Kaposi's sarcoma.

LEAPChem combines experience and expertise in the distribution of hazardous and non-hazardous raw materials to its professional customer base. Working alongside an elite network of manufacturers, carriers and warehouses, we are equipped to deliver your product safely and efficiently, throughout every step of the supply chain.

If you are interested in Doxorubicin hydrochloride, click here to send an inquiry!

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References:

https://en.wikipedia.org/wiki/Doxorubicin

https://www.ncbi.nlm.nih.gov/pubmed/24211979

https://www.ncbi.nlm.nih.gov/pubmed/4009823

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2018年10月24日星期三

LEAPChem Has Germanium dioxide (1310-53-8) Now!

If you are interested in Germanium dioxide or its derivatives, look no further than LEAPChem - Pharmaceutical Chemicals. We are an ISO:9001 certified organization attesting to the highest quality management practices in the pharmaceutical chemicals industry. Our professional team of technical specialists, logistics, compliance and customer service experts will provide a safe, time efficient, and cost-effective process from manufacturer to delivery at the port or warehouse of your choice.

Basic Information of Germanium dioxide

Chemical Name: Germanium dioxide

Cas No.: 1310-53-8

Molecular Formula: GeO2

Chemical Structure:

Germanium dioxide, also called germanium oxide and germania, is an inorganic compound with the chemical formula GeO2. It is the main commercial source of germanium. It also forms as a passivation layer on pure germanium in contact with atmospheric oxygen.

The refractive index (1.7) and optical dispersion properties of germanium dioxide makes it useful as an optical material for wide-angle lenses, in optical microscope objective lenses, and for the core of fiber-optic lines. See Optical fiber for specifics on the manufacturing process. Both Germanium and its glass oxide, GeO2 are transparent to the infrared spectrum. The glass can be manufactured into IR windows and lenses, used for night-vision technology in the military, luxury vehicles, and Thermographic cameras. GeO2 is preferred over other IR transparent glasses because it is mechanically strong and therefore preferred for rugged military usage.

A mixture of silicon dioxide and germanium dioxide ("silica-germania") is used as an optical material for optical fibers and optical waveguides. Controlling the ratio of the elements allows precise control of refractive index. Silica-germania glasses have lower viscosity and higher refractive index than pure silica. Germania replaced titania as the silica dopant for silica fiber, eliminating the need for subsequent heat treatment, which made the fibers brittle.

Germanium dioxide is also used as a catalyst in production of polyethylene terephthalate resin, and for production of other germanium compounds. It is used as a feedstock for production of some phosphors and semiconductor materials.

Germanium dioxide is used in algaculture as an inhibitor of unwanted diatom growth in algal cultures, since contamination with the comparatively fast-growing diatoms often inhibits the growth of or outcompetes the original algae strains. GeO2 is readily taken up by diatoms and leads to silicon being substituted by germanium in biochemical processes within the diatoms, causing a significant reduction of the diatoms' growth rate or even their complete elimination, with little effect on non-diatom algal species. For this application, the concentration of germanium dioxide typically used in the culture medium is between 1 and 10 mg/l, depending on the stage of the contamination and the species.

LEAPChem is continually expanding its scope within the pharmaceutical chemicals industry. Our passion for professional development enables us to accommodate our customers’ chemical requirements, and to distribute chemicals with applications that span several classes and functions.

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References:

https://en.wikipedia.org/wiki/Germanium_dioxide

https://www.ncbi.nlm.nih.gov/pubmed/17193468

https://www.ncbi.nlm.nih.gov/pubmed/22947505

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2018年10月22日星期一

Order Trichloroacetic acid (76-03-9) from LEAPChem.com Now!

LEAPChem - Pharmaceutical Chemicals is a premier supplier of pharmaceutical chemicals and other chemical raw materials for global customers including drug manufacturers, universities, research labs, R&D centers, and other industries that use chemical raw materials such as polymers, textiles, agriculture, coatings, etc. As an ISO 9001:2015 certified company, our team of experts in customer service, product sourcing, logistics, regulatory and compliance operate at the highest standard. LEAPChem's experienced sales team will work tirelessly to find the chemicals you need for a price you can afford. As the name suggests, LEAPChem pharmaceutical chemicals specializes in providing you with those difficult to acquire niche chemicals. We are, however, just as eager and able to provide widely used and recognized chemicals to our valued clients. Consistent with being a multi-industry chemical provider, LEAPChem is excited to highlight Trichloroacetic acid.

Basic Information of Trichloroacetic acid

Chemical Name: Trichloroacetic acid

Cas No.: 76-03-9

Molecular Formula: C2HCl3O2

Chemical Structure:

Trichloroacetic acid (TCA; TCAA; also known as trichloroethanoic acid) is an analogue of acetic acid in which the three hydrogen atoms of the methyl group have all been replaced by chlorine atoms. Salts and esters of trichloroacetic acid are called trichloroacetates.

It is widely used in biochemistry for the precipitation of macromolecules, such as proteins, DNA, and RNA. TCA and DCA are both used in cosmetic treatments (such as chemical peels and tattoo removal) and as topical medication for chemoablation of warts, including genital warts. It can kill normal cells as well. It is considered safe for use for this purpose during pregnancy.

A trichloroacetic acid warts removal solution can be used if you wish to treat warts or verrucas at home. However, unlike formic acid solutions, trichloroacetic acid should not be used on children under the age of four. Additionally, if you are diabetic, pregnant or lactating, you should consult a doctor before using TCA treatment. The efficacy of TCA treatment is largely dependent on the concentration of the TCA solution. Unlike formic acid solutions, which have a dehydrating effect, removing the whole wart with TCA can be challenging. Removing the whole wart is necessary to avoid recurrence.

Trichloroacetic acid peels are great for evening out skin tone and getting rid of imperfections, and, unlike AHA peels, they can even get rid of finer wrinkles. The results tend to be more noticeable than those of AHA peels, but less drastic than those achieved with phenol peels. Recovery time follows the same pattern. It takes longer to recover from a trichloroacetic acid peel than an AHA peel, but much less time than a phenol peel.

Unlike phenol peels, trichloroacetic acid peels can be effective for people with darker skin. They are less likely to leave your skin looking permanently bleached, but that doesn't mean there isn't any chance of discoloration. As far as popularity goes, trichloroacetic acid peels are right up there with AHA peels. This is largely because the concentration of trichloroacetic acid can be altered to produce results similar to those of both AHA peels and phenol peels. Even better, the whole procedure takes less time than watching a sitcom.

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References:

https://en.wikipedia.org/wiki/Trichloroacetic_acid

https://www.ncbi.nlm.nih.gov/pubmed/26849087

https://www.ncbi.nlm.nih.gov/pubmed/3412028

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2018年10月18日星期四

Buy Potassium clavulanate (61177-45-5) from LEAPChem.com Now!

As an experienced supplier of pharmaceutical chemicals for more than 10 years, LEAPChem - Pharmaceutical Chemicals is fully equipped to fill your pharmaceutical chemical requirements efficiently and exceed your expectations. Our customer service team is always ready to provide a personal touch to every conversation and ensure quick reply, professional support, and reliability at every step. We offer various pack sizes and configurations to suit your needs, and our experienced staff stays with you every step of the way, from inquiry through delivery. Consistent with being a multi-industry chemical provider, LEAPChem is excited to highlight Potassium clavulanate.

Basic Information of Potassium clavulanate

Chemical Name: Potassium clavulanate

Cas No.: 61177-45-5

Molecular Formula: C8H9NO5

Chemical Structure:

Clavulanic acid is a β-lactam drug that functions as a mechanism-based β-lactamase inhibitor. While not effective by itself as an antibiotic, when combined with penicillin-group antibiotics, it can overcome antibiotic resistance in bacteria that secrete β-lactamase, which otherwise inactivates most penicillins. In its most common form, the potassium salt potassium clavulanate is combined with amoxicillin (co-amoxiclav, trade names Augmentin, Tyclav, Synulox (veterinary), and others) and ticarcillin (co-ticarclav, trade name entin).

For the treatment of pyelonephritis during pregnancy, and for the treatment of pyelonephritis caused by gram-positive organisms, amoxicillin or amoxicillin-clavulanate potassium is preferred.

Clavulanic acid is biosynthesized from the amino acid arginine and the sugar glyceraldehyde 3-phosphate. With the β-lactam like structure, clavulanic acid looks structurally similar to penicillin, but the biosynthesis of this molecule involves a different pathway and set of enzymes. Clavulanic acid is biosynthesized by the bacterium Streptomyces clavuligerus, using glyceraldehyde-3-phosphate and L-arginine as the starting materials of the pathway. Although all of the intermediates of the pathway are known, the exact mechanism of each enzymatic reaction is not fully understood. The biosynthesis mainly involves 3 enzymes: clavaminate synthase, β-lactam synthetase and N2-(2-carboxyethyl)-L-arginine synthase(CEA). Clavaminate synthase is a non-heme iron α-keto-glutarate dependent oxygenase that is encoded by orf5 of the clavulanic acid gene cluster. The specific mechanism of how this enzyme works is not fully understood, but this enzyme regulates 3 steps in the overall synthesis of clavulanic acid. All 3 steps occur in the same region of the catalytic iron center, yet do not occur in-sequence and affect different areas of the clavulanic acid structure.

The use of clavulanic acid with penicillins has been associated with an increased incidence of cholestatic jaundice and acute hepatitis during therapy or shortly after. The associated jaundice is usually self-limiting and very rarely fatal.

The UK Committee on Safety of Medicines (CSM) recommends that treatments such as amoxicillin/clavulanic acid preparations be reserved for bacterial infections likely to be caused by amoxicillin-resistant β-lactamase-producing strains, and that treatment should not normally exceed 14 days.

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References:

https://en.wikipedia.org/wiki/Clavulanic_acid

https://www.ncbi.nlm.nih.gov/pubmed/19564277

https://www.ncbi.nlm.nih.gov/pubmed/6739312

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LEAPChem Supplies Hemin (16009-13-5) Now!

As the name suggests, LEAPChem - Pharmaceutical Chemicals specializes in providing you with those difficult to acquire niche chemicals. We are, however, just as eager and able to provide widely used and recognized chemicals to our valued clients. LEAPChem combines experience and expertise in the distribution of hazardous and non-hazardous raw materials to its professional customer base. Working alongside an elite network of manufacturers, carriers and warehouses, we are equipped to deliver your product safely and efficiently, throughout every step of the supply chain. Consistent with being a multi-industry chemical provider, LEAPChem is excited to highlight Hemin.

Basic Information of Hemin

Chemical Name: Hemin

Cas No.: 16009-13-5

Molecular Formula: C34H32ClFeN4O4

Chemical Structure:

Hemin (haemin; ferric chloride heme) is an iron-containing porphyrin with chlorine that can be formed from a haem group, such as haem b found in the haemoglobin of human blood.

Hemin is protoporphyrin IX containing a ferric iron (Fe3+) ion with a coordinating chloride ligand.

Chemically, hemin differs from the related heme-compound hematin chiefly in that the coordinating ion is a chloride ion in hemin, whereas the coordinating ion is an hydroxide ion in hematin. The iron ion in haem is ferrous (Fe2+), whereas it is ferric (Fe3+) in both hemin and hematin.

Hemin is endogenously produced in the human body, for example during the turnover of old red blood cells. It can form inappropriately as a result of hemolysis or vascular injury. Several proteins in human blood bind to hemin, such as hemopexin and serum albumin.

A lyophilised form of hemin is used as a pharmacological agent in certain cases for the treatment of porphyria attacks, particularly in acute intermittent porphyria. Administration of hemin can reduce haem deficits in such patients, thereby suppressing the activity of delta-amino-levulinic acid synthase (a key enzyme in the synthesis of the porphyrins) by biochemical feedback, which in turn reduces the production of porphyrins and of the toxic precursors of haem. In such pharmacological contexts, hemin is typically formulated with human albumin prior to administration by a medical professional, to reduce the risk of phlebitis and to stabilise the compound, which is potentially reactive if allowed to circulate in free-form. Such pharmacological forms of hemin are sold under a range of trade names including the trademarks Panhematin® and Normosang®.

Hemin is a fraction derived from processed red blood cells. It is a salt which inhibits the production of a chemical compounds called porphyrins.

Porphryias are a rare group of disorders in which the porphyrins that the body produces are not broken down effectively and so these begin to build up. Porphyria is usually a hereditary disease. It can lead to symptoms such as light sensitivity which causes rashes, abdominal pain or cramping or problems with the nervous or muscular system.

A treatment for porphyria is the administration of hemin. This is done so as to reduce the porphyrins in the body to normal levels. Hemin can only be used under a doctor's care and can only be given intravenously.

If you are interested in Hemin, click here to send an inquiry!

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References:

https://en.wikipedia.org/wiki/Hemin

https://www.ncbi.nlm.nih.gov/pubmed/16945618

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC278836/

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