LEAPChem
- Pharmaceutical Chemicals is an ISO:9001 certified organization, which shows
our high reputation track record for providing high quality management in the
pharmaceutical chemicals industry. From initial inquiry through safe and
efficient delivery, our team has the experience and professionalism to secure
any pharmaceutical chemicals in your preferred grade, pack size and pack form,
and deliver your products accurately, on time and on budget to every corner of
the world. LEAPChem Highlights Guanidine hydrochloride today!
Basic
Information of Guanidine hydrochloride
Chemical Name: Guanidine hydrochloride
Cas No.: 50-01-1
Molecular Formula: CH5N3.HCl
Chemical Structure:
Guanidinium chloride
or guanidine hydrochloride, usually abbreviated GuHCl and sometimes GdnHCl or
GdmCl, is the hydrochloride salt of guanidine. Guanidinium chloride is a strong
chaotrope and one of the strongest denaturants used in physiochemical studies
of protein folding. Guanidine Hydrochloride also has the ability to decrease
enzyme activity and increase the solubility of hydrophobic molecules. At high
concentrations of guanidinium chloride (e.g., 6 M), proteins lose their ordered
structure, and they tend to become randomly coiled, i.e. they do not contain
any residual structure. However, at concentrations in the millimolar range in
vivo, guanidinium chloride has been shown to "cure" prion positive
cells (i.e. cells exhibiting a prion positive phenotype revert to a prion negative
phenotype). This is the result of inhibition of the Hsp104 chaperone protein
known to play an important role in prion fiber fragmentation and propagation.
Guanidine hydrochloride is indicated for
the reduction of the symptoms of muscle weakness and easy fatigability
associated with Eaton-Lambert syndrome. It is not indicated for treating
myasthenia gravis. It apparently acts by enhancing the release of acetylcholine
following a nerve impulse. It also appears to slow the rates of depolarization
and repolarization of muscle cell membranes. Initial dosage is usually between
10 and 15 mg/kg (5 to 7 mg/pound) of body weight per day in 3 or 4 divided
doses. This dosage may be gradually increased to a total daily dosage of 35
mg/kg (16 mg/pound) of body weight per day or up to the development of side
effects. Side effects include increased peristalsis and diarrhea. Fatal
bone-marrow suppression, apparently dose related, can occur with guanidine.
As an experienced supplier of
pharmaceutical chemicals for more than 10 years, LEAPChem is fully equipped to
fill your pharmaceutical chemical requirements efficiently and exceed your
expectations. Our customer service team is always ready to provide a personal
touch to every conversation and ensure quick reply, professional support, and
reliability at every step.
If you are interested in Guanidine hydrochloride, click here to send an inquiry!
Make LEAPChem your pharmaceutical chemicals
long-term partner and contact
us today!
References:
https://en.wikipedia.org/wiki/Guanidinium_chloride
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2142645/
https://www.ncbi.nlm.nih.gov/pubmed/19594171
Related Articles
没有评论:
发表评论