2018年11月26日星期一

LEAPChem Has Fulvestrant (129453-61-8) Now!



If you are interested in Fulvestrant, look no further than LEAPChem - Pharmaceutical Chemicals. We are an ISO:9001 certified organization attesting to the highest quality management practices in the pharmaceutical chemicals industry. Our professional team of technical specialists, logistics, compliance and customer service experts will provide a safe, time efficient, and cost-effective process from manufacturer to delivery at the port or warehouse of your choice. LEAPChem Highlights Fulvestrant today!

Basic Information of Fulvestrant
Chemical Name: Fulvestrant
Cas No.: 129453-61-8
Molecular Formula: C32H47F5O3S
Chemical Structure:



Fulvestrant, sold under the brand name Faslodex among others, is a medication used to treat hormone receptor (HR)-positive metastatic breast cancer in postmenopausal women with disease progression as well as HR-positive, HER2-negative advanced breast cancer in combination with palbociclib in women with disease progression after endocrine therapy. It is given by injection into a muscle.
Fulvestrant is a selective estrogen receptor degrader (SERD) and was first-in-class to be approved. It works by binding to the estrogen receptor and destabilizing it, causing the cell's normal protein degradation processes to destroy it.
Fulvestrant is used for the treatment of hormone receptor positive metastatic breast cancer or locally advanced unresectable disease in postmenopausal women; it is given by injection. A 2017 Cochrane review found it is as safe and effective as first line or second line endocrine therapy.
It is also used to treat HR-positive, HER2-negative advanced or metastatic breast cancer in combination with palbociclib in women with disease progression after first-line endocrine therapy.
Hormones are chemical substances that are produced by glands in the body, which enter the bloodstream and cause effects in other tissues. For example, the hormone testosterone made in the testicles and is responsible for male characteristics such as deepening voice and increased body hair. The use of hormone therapy to treat cancer is based on the observation that receptors for specific hormones that are needed for cell growth are on the surface of some tumor cells.  Hormone therapies work by stopping the production of a certain hormone, blocking hormone receptors, or substituting chemically similar agents for the active hormone, which cannot be used by the tumor cell.  The different types of hormone therapies are categorized by their function and/or the type of hormone that is affected.
Many breast cancers have estrogen receptors, and the growth of these tumors can be stimulated by estrogen. Fulvestrant is an estrogen receptor downregulator, this means it binds to the estrogen receptor site in competition with estrogen in the body.  Once it binds to the site it causes the receptors to break down, thereby preventing normal cellular response to estrogen.
Fulvestrant is a selective estrogen receptor degrader (SERD).
It works by binding to the estrogen receptor and making it more hydrophobic, which makes the receptor unstable and misfold, which in turn leads normal processes inside the cell to degrade it.
Fulvestrant is slowly absorbed and maximum plasma concentrations (Cmax) are reached after about 5 days and the terminal half-life is around 50 days. Fulvestrant is highly (99%) bound to plasma proteins including very low density lipoprotein, low density lipoprotein, and high density lipoprotein. It appears to be metabolized along the same pathways as endogenous steroids; CYP3A4 may be involved, but non-cytochrome routes appear to be more important. It does not inhibit any CYP450 enzymes. Elimination is almost all via feces.

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References:
https://en.wikipedia.org/wiki/Fulvestrant
https://www.ncbi.nlm.nih.gov/pubmed/20156170
https://www.ncbi.nlm.nih.gov/pubmed/16198056

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Lead acetate trihydrate (6080-56-4) is Available in LEAPChem Now!



Allow a company with a ISO 9001 certification to handle all your pharmaceutical chemical needs. From finding a reliable manufacturer who creates a quality product meeting your specifications, to shipping to the port or facility to your choice, LEAPChem - Pharmaceutical Chemicals experienced and professional staff will make the process as smooth as possible. LEAPChem Highlights Lead acetate trihydrate today!

Basic Information of Lead acetate trihydrate
Chemical Name: Lead acetate trihydrate
Cas No.: 6080-56-4
Molecular Formula: Pb(C2H3O2)2
Chemical Structure:
 

Lead(II) acetate (Pb(CH3COO)2), also known as lead acetate, lead diacetate, plumbous acetate, sugar of lead, lead sugar, salt of Saturn, or Goulard's powder, is a white crystalline chemical compound with a sweetish taste. It is made by treating lead(II) oxide with acetic acid. Like other lead compounds, it is toxic. Lead acetate is soluble in water and glycerin. With water it forms the trihydrate, Pb(CH3COO)2·3H2O, a colourless or white efflorescent monoclinic crystalline substance.
The substance is used as a reagent to make other lead compounds and as a fixative for some dyes. In low concentrations, it is the principal active ingredient in progressive types of hair colouring dyes. Lead(II) acetate is also used as a mordant in textile printing and dyeing, and as a drier in paints and varnishes. It was historically used as a sweetener and for cosmetics.
Like other lead(II) salts, lead(II) acetate has a sweet taste, which led to its historical use as a sugar substitute. The ancient Romans, who had few sweeteners besides honey, would boil must (grape juice) in lead pots to produce a reduced sugar syrup called defrutum, concentrated again into sapa. This syrup was used to sweeten wine and to sweeten and preserve fruit. It is possible that lead(II) acetate or other lead compounds leaching into the syrup might have caused lead poisoning in those who consumed it. Lead acetate is no longer used in the production of sweeteners because of its recognized toxicity. Modern chemistry can easily detect it, which has almost completely stopped the illegal use that continued decades after legal use as a sweetener was banned.
Lead(II) acetate paper is used to detect the poisonous gas hydrogen sulfide. The gas reacts with lead(II) acetate on the moistened test paper to form a grey precipitate of lead(II) sulfide.
An aqueous solution of lead(II) acetate is the byproduct of the 50/50 mixture of hydrogen peroxide and white vinegar used in the cleaning and maintenance of stainless steel firearm suppressors (silencers) and compensators. The solution is agitated by the bubbling action of the hydrogen peroxide, and the main reaction is the dissolution of lead deposits within the suppressor by the acetic acid, which forms lead acetate. Because of its high toxicity, this chemical solution must be appropriately disposed by a chemical processing facility or hazardous materials centre. Alternatively, the solution may be reacted with sulfuric acid to precipitate nearly insoluble lead(II) sulfate. The solid may then be removed by mechanical filtration and is safer to dispose of than aqueous lead acetate.

As an experienced supplier of pharmaceutical chemicals for more than 10 years, LEAPChem is fully equipped to fill your pharmaceutical chemical requirements efficiently and exceed your expectations. Our customer service team is always ready to provide a personal touch to every conversation and ensure quick reply, professional support, and reliability at every step.

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References:
https://en.wikipedia.org/wiki/Lead(II)_acetate
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1470238/
https://www.ncbi.nlm.nih.gov/pubmed/9114341

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Order 1-Naphthalene acetic acid (86-87-3) from LEAPChem Now!



Searching for niche products has always been a problem. You have to spend much valuable time looking for a supplier, and then you need to make sure the provider is reputable. Usually, successfully finding a reputable, reliable, and responsible supplier of high quality chemicals must be a headache. Relax now, because those days are over! By coming to the LEAPChem - Pharmaceutical Chemicals website, you have come one step closer to acquiring your trouble free pharmaceutical chemicals. LEAPChem Highlights 1-Naphthalene acetic acid today!

Basic Information of 1-Naphthalene acetic acid
Chemical Name: 1-Naphthalene acetic acid
Cas No.: 86-87-3
Molecular Formula: C12H10O2
Chemical Structure:



1-Naphthaleneacetic acid (NAA) is an organic compound with the formula C10H7CH2CO2H. This colorless solid is soluble in organic solvents. It features a carboxylmethyl group (CH2CO2H) linked to the "1-position" of naphthalene. NAA is a synthetic plant hormone in the auxin family and is an ingredient in many commercial plant rooting horticultural products; it is a rooting agent and used for the vegetative propagation of plants from stem and leaf cutting. It is also used for plant tissue culture.
The hormone NAA does not occur naturally, and, like all auxins, is toxic to plants at high concentrations. In the United States, under the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA), products containing NAA require registration with the Environmental Protection Agency (EPA) as pesticides.
NAA is widely used in agriculture for various purposes. It is considered to be only slightly toxic but when at higher concentrations it can be toxic to animals. This was shown when tested on rats via oral ingestion at 1000–5900 mg/kg. NAA has been shown to greatly increase cellulose fiber formation in plants when paired with another phytohormone called gibberellic acid. Because it is in the auxin family it has also been understood to prevent premature dropping and thinning of fruits from stems. It is applied after blossom fertilization. Increased amounts of it can actually have negative effects however, and cause growth inhibition to the development of plant crops. It has been used on many different crops including apples, olives, oranges, potatoes, and various other hanging fruits. In order for it to obtain its desired effects it must be applied in concentrations ranging from 20–100 µg/mL. NAA present in the environment undergoes oxidation reactions with hydroxyl radicals and sulphate radicals. Radical reactions of NAA was studied by using pulse radiolysis technique. Hydroxyl adduct radical was formed as the intermediate during the reaction of hydroxyl radical with NAA. The intermediate Naphtyl methyl radical was formed during the reaction of sulphate radical anion with NAA.
In micro propagation of various plants NAA is typically added to a media containing nutrients essential to the plants survival. It is added to help induce root formation in various plant types. It can also be applied by spraying it onto plants and which is typical in agricultural use. It is prohibited in many areas to use it in high concentrations due to the health concerns towards humans and other animals.

At LEAPChem, we place emphasis on the importance of each step of the distribution process. From sourcing, to supply chain logistics, to customer service, and the technical know-how in between, LEAPChem is a trusted industry leader. We will be the strongest link in your supply chain and help you to get the products you need accurately, on time, and on budget.

If you are interested in 1-Naphthalene acetic acid, click here to send an inquiry!
Make LEAPChem your pharmaceutical chemicals long-term partner and contact us today!

References:
https://en.wikipedia.org/wiki/1-Naphthaleneacetic_acid
https://www.ncbi.nlm.nih.gov/pubmed/9697346
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC366374/

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2018年11月25日星期日

LEAPChem Has Cefixime (79350-37-1) Now!



At LEAPChem - Pharmaceutical Chemicals, we proudly distribute the materials that are required for the wide range of our customers’ production processes. We understand that each production process is unique, which is why we provide custom services and chemical knowledge tailored to each customer specifically. With LEAPChem, you can look forward to receiving the operational benefits of working with an international company paired with the customer service and reliable follow up of a small business. LEAPChem Highlights Cefixime today!

Basic Information of Cefixime
Chemical Name: Cefixime
Cas No.: 79350-37-1
Molecular Formula: C16H15N5O7S2
Chemical Structure:



Cefixime is an antibiotic useful to treat a number of bacterial infections. This includes otitis media, strep throat, pneumonia, urinary tract infections, gonorrhea, and Lyme disease. For gonorrhea typically only one dose is required. In the United States it is a second line treatment to ceftriaxone for gonorrhea. It is taken by mouth.
Common side effects include diarrhea, abdominal pain, and nausea. Serious side effects may include allergic reactions and Clostridium difficile diarrhea. It is not recommended in people with a history of a severe penicillin allergy. It appears to be relatively safe during pregnancy. It is in the third generation cephalosporin class of medications. It works by disrupting the bacteria's cell wall resulting in its death.
Cefixime is a semi-synthetic (partially man-made), oral antibiotic in the cephalosporin family of antibiotics. The cephalosporin family includes cephalexin (Keflex), cefaclor (Ceclor), cefuroxime (Zinacef), cefpodoxime (Vantin), cefprozil (Cefzil), and many injectable forms. Like other cephalosporins, cefixime stops bacteria from multiplying by preventing bacteria from forming the walls that surround them. The walls are necessary to protect bacteria from their environment and to keep the contents of the bacterial cell together; most bacteria cannot survive without a cell wall. Cefixime is active against a very wide spectrum of bacteria such as Staphylococcus aureus, Streptococcus pneumoniae, Streptococcus pyogenes (the cause of strep throat), Hemophilus influenzae, Moraxella catarrhalis, E. coli, Klebsiella, Proteus mirabilis, Salmonella, Shigella, and Neisseria gonorrhoeae. The FDA approved cefixime in April 1989.

As an industry leader in chemical sourcing, LEAPChem has strong relationships with vendors, suppliers, and customers worldwide that allow us to access hard to find chemicals at competitive prices. Our warehouses are equipped to handle kosher, organic, hazardous, and non-hazardous materials. We have established partnerships with import and export providers making seamless international shipping possible.

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Make LEAPChem your pharmaceutical chemicals long-term partner and contact us today!

References:
https://en.wikipedia.org/wiki/Cefixime
https://www.ncbi.nlm.nih.gov/pubmed/9404906
https://www.ncbi.nlm.nih.gov/pubmed/2530548

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