As the name suggests, LEAPChem - Pharmaceutical Chemicals specializes
in providing you with those difficult to acquire niche chemicals. We are,
however, just as eager and able to provide widely used and recognized chemicals
to our valued clients. LEAPChem combines experience and expertise in the
distribution of hazardous and non-hazardous raw materials to its professional
customer base. Working alongside an elite network of manufacturers, carriers
and warehouses, we are equipped to deliver your product safely and efficiently,
throughout every step of the supply chain. Consistent with being a
multi-industry chemical provider, LEAPChem is excited to highlight Hemin.
Basic
Information of Hemin
Chemical Name: Hemin
Cas No.: 16009-13-5
Molecular Formula: C34H32ClFeN4O4
Chemical Structure:
Hemin (haemin;
ferric chloride heme) is an iron-containing porphyrin with chlorine that can be
formed from a haem group, such as haem b found in the haemoglobin of human
blood.
Hemin is protoporphyrin IX containing a
ferric iron (Fe3+) ion with a coordinating chloride ligand.
Chemically, hemin differs from the related
heme-compound hematin chiefly in that the coordinating ion is a chloride ion in
hemin, whereas the coordinating ion is an hydroxide ion in hematin. The iron
ion in haem is ferrous (Fe2+), whereas it is ferric (Fe3+) in both hemin and
hematin.
Hemin is endogenously produced in the human
body, for example during the turnover of old red blood cells. It can form
inappropriately as a result of hemolysis or vascular injury. Several proteins
in human blood bind to hemin, such as hemopexin and serum albumin.
A lyophilised form of hemin is used as a
pharmacological agent in certain cases for the treatment of porphyria attacks,
particularly in acute intermittent porphyria. Administration of hemin can
reduce haem deficits in such patients, thereby suppressing the activity of
delta-amino-levulinic acid synthase (a key enzyme in the synthesis of the
porphyrins) by biochemical feedback, which in turn reduces the production of
porphyrins and of the toxic precursors of haem. In such pharmacological
contexts, hemin is typically formulated with human albumin prior to
administration by a medical professional, to reduce the risk of phlebitis and
to stabilise the compound, which is potentially reactive if allowed to
circulate in free-form. Such pharmacological forms of hemin are sold under a
range of trade names including the trademarks Panhematin® and Normosang®.
Hemin is a fraction derived from processed
red blood cells. It is a salt which inhibits the production of a chemical
compounds called porphyrins.
Porphryias are a rare group of disorders in
which the porphyrins that the body produces are not broken down effectively and
so these begin to build up. Porphyria is usually a hereditary disease. It can
lead to symptoms such as light sensitivity which causes rashes, abdominal pain
or cramping or problems with the nervous or muscular system.
A treatment for porphyria is the
administration of hemin. This is done so as to reduce the porphyrins in the
body to normal levels. Hemin can only be used under a doctor's care and can
only be given intravenously.
LEAPChem is continually expanding its scope
within the pharmaceutical chemicals industry. Our passion for professional
development enables us to accommodate our customers’ chemical requirements, and
to distribute chemicals with applications that span several classes and
functions.
If you are interested in Hemin, click here to send an inquiry!
Make LEAPChem your pharmaceutical chemicals
long-term partner and contact
us today!
References:
https://en.wikipedia.org/wiki/Hemin
https://www.ncbi.nlm.nih.gov/pubmed/16945618
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC278836/
Related Articles
没有评论:
发表评论