As an experienced supplier of
pharmaceutical chemicals for more than 10 years, LEAPChem - Pharmaceutical Chemicals is fully
equipped to fill your pharmaceutical chemical requirements efficiently and
exceed your expectations. Our customer service team is always ready to provide
a personal touch to every conversation and ensure quick reply, professional
support, and reliability at every step. We offer various pack sizes and
configurations to suit your needs, and our experienced staff stays with you
every step of the way, from inquiry through delivery. Consistent with being a
multi-industry chemical provider, LEAPChem is excited to highlight Potassium clavulanate.
Basic
Information of Potassium clavulanate
Chemical Name: Potassium clavulanate
Cas No.: 61177-45-5
Molecular Formula: C8H9NO5
Chemical Structure:
Clavulanic acid is a β-lactam drug that
functions as a mechanism-based β-lactamase inhibitor. While not effective by
itself as an antibiotic, when combined with penicillin-group antibiotics, it
can overcome antibiotic resistance in bacteria that secrete β-lactamase, which
otherwise inactivates most penicillins. In its most common form, the potassium
salt potassium clavulanate is combined with amoxicillin (co-amoxiclav, trade names
Augmentin, Tyclav, Synulox (veterinary), and others) and ticarcillin
(co-ticarclav, trade name entin).
For the treatment of pyelonephritis during
pregnancy, and for the treatment of pyelonephritis caused by gram-positive
organisms, amoxicillin or amoxicillin-clavulanate potassium is preferred.
Clavulanic acid is biosynthesized from the
amino acid arginine and the sugar glyceraldehyde 3-phosphate. With the β-lactam
like structure, clavulanic acid looks structurally similar to penicillin, but
the biosynthesis of this molecule involves a different pathway and set of
enzymes. Clavulanic acid is biosynthesized by the bacterium Streptomyces
clavuligerus, using glyceraldehyde-3-phosphate and L-arginine as the starting materials
of the pathway. Although all of the intermediates of the pathway are known, the
exact mechanism of each enzymatic reaction is not fully understood. The
biosynthesis mainly involves 3 enzymes: clavaminate synthase, β-lactam
synthetase and N2-(2-carboxyethyl)-L-arginine synthase(CEA). Clavaminate
synthase is a non-heme iron α-keto-glutarate dependent oxygenase that is
encoded by orf5 of the clavulanic acid gene cluster. The specific mechanism of
how this enzyme works is not fully understood, but this enzyme regulates 3
steps in the overall synthesis of clavulanic acid. All 3 steps occur in the
same region of the catalytic iron center, yet do not occur in-sequence and
affect different areas of the clavulanic acid structure.
The use of clavulanic acid with penicillins
has been associated with an increased incidence of cholestatic jaundice and
acute hepatitis during therapy or shortly after. The associated jaundice is
usually self-limiting and very rarely fatal.
The UK Committee on Safety of Medicines
(CSM) recommends that treatments such as amoxicillin/clavulanic acid
preparations be reserved for bacterial infections likely to be caused by
amoxicillin-resistant β-lactamase-producing strains, and that treatment should
not normally exceed 14 days.
LEAPChem is continually expanding its scope
within the pharmaceutical chemicals industry. Our passion for professional
development enables us to accommodate our customers’ chemical requirements, and
to distribute chemicals with applications that span several classes and
functions.
If you are interested in Potassium clavulanate, click here to send an inquiry!
Make LEAPChem your pharmaceutical chemicals
long-term partner and contact
us today!
References:
https://en.wikipedia.org/wiki/Clavulanic_acid
https://www.ncbi.nlm.nih.gov/pubmed/19564277
https://www.ncbi.nlm.nih.gov/pubmed/6739312
Related Articles
没有评论:
发表评论