LEAPChem
- Pharmaceutical Chemicals is a premier supplier of pharmaceutical
chemicals and other chemical raw materials for global customers including drug
manufacturers, universities, research labs, R&D centers, and other
industries that use chemical raw materials such as polymers, textiles,
agriculture, coatings, etc. As an ISO 9001:2015 certified company, our team of
experts in customer service, product sourcing, logistics, regulatory and
compliance operate at the highest standard. LEAPChem's experienced sales team
will work tirelessly to find the chemicals you need for a price you can afford.
One such material is our current featured product, Dimethyl fumarate.
Basic
Information of Dimethyl fumarate
Chemical Name: Dimethyl fumarate
Cas No.: 624-49-7
Molecular Formula: C6H8O4
Chemical Structure:
Dimethyl fumarate
(DMF) is the methyl ester of fumaric acid. DMF was initially recognized as a
very effective hypoxic cell radiosensitizer. Later, DMF combined with three
other fumaric acid esters (FAE) was licensed in Germany as oral therapy for
psoriasis (trade name Fumaderm). Other diseases, such as necrobiosis lipoidica,
granuloma annulare, and sarcoidosis were also found to respond to treatment
with DMF in case reports or small patient series. Phase III clinical trials
found that DMF (BG-12) successfully reduced relapse rate and increased time to
progression of disability in multiple sclerosis (trade name Tecfidera). DMF is
thought to have immunomodulatory properties without significant
immunosuppression.
Dimethyl fumarate was shown to have a
significant effect on relapse rate and time to progression in phase III
clinical trials of multiple sclerosis. Several methods exist for the laboratory
synthesis of dimethyl fumarate, with reported methods alkene isomerization of
dimethyl maleate, and Fischer esterification of fumaric acid. Dimethyl fumarate
is an ester and an α,β-unsaturated electrophilic compound which can quickly
undergo Michael additions with nucleophiles. Dimethyl fumarate is also an
effective diene acceptor in the thermal Diels-Alder reaction, where the
reactivity of its vinylenic bond is enhanced by the two electron-withdrawing
ester groups. Due to the geometry of the starting ester, the Diels-Alder
product will have a trans configuration. With this reaction, compounds with
bicyclo skeletons can be synthesized, e.g. a diester with a norbornene skeleton
from dimethyl fumarate and cyclopentadiene.
We offer various pack sizes and
configurations to suit your needs, and our experienced staff stays with you
every step of the way, from inquiry through delivery.
If you are interested in Dimethyl fumarate, click here to send an inquiry!
Make LEAPChem your pharmaceutical chemicals
long-term partner and contact
us today!
References:
https://en.wikipedia.org/wiki/Dimethyl_fumarate
https://www.ncbi.nlm.nih.gov/pubmed/29128972
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4780395/
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